PAProC II will predict cleavages by two proteasome species:
constitutive proteasomes and immunoproteasomes. The predictions of
PAProC II are based on data published recently
(R.E.M. Toes, A.K. Nussbaum, M. Schirle, M. Kraft, N.P.N. Emmerich,
A. Zweinderman, T.P. Dick, J. Müller, B. Schönfisch, S. Stevanovic,
H.-G. Rammensee, H. Schild, Discrete cleavage motifs of constitutive
and immunoproteasomes revealed by quantitative analysis of cleavage
products, Journal of Experimental Medicine 194, 1-12, 2001).
We are currently preparing a manuscript showing the improved
predictions of PAProC II, as compared to PAProC I, especially for
immunologically relevant cleavages producing MHC class I ligands and
CTL epitopes.
PAProC II is now available as a trial version. You can register now and will receive
further information by e-mail.
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